- 姓 名：
- 谢梦
- 职 称：
- 助理研究员
- 研究领域：
- 代谢生物学 发育生物学
- 通信地址：
- 3200威尼斯vip吕志和楼329
- 电子邮件：
- meng.xie@pku.edu.cn
谢梦博士于2007年毕业于英国曼彻斯特大学生命科学系（University of Manchester，Department of Life Science）获得药理学学士学位。期间在英国柴郡阿斯利康制药公司（AstraZeneca, Cheshire, UK）全职实习一年(2005-2006)。
2008年毕业于英国曼彻斯特大学生命科学系（University of Manchester，Department of Life Science），获得分子生物学硕士学位。
2014年毕业于加拿大麦吉尔大学生物系（McGill University, Department of Biology），获得生物学博士学位。
2015至2020年，于瑞典卡罗林斯卡医学院从事博士后研究工作。
2020年12月起任任3200威尼斯vip助理研究员、IDG麦戈文脑科学研究所Co-PI（Carlos Ibanez教授课题组）。
主持科研项目：
1. 瑞典卡罗林斯卡医学院, Ulla and Gustaf af Uggla Foundation on arthropathic diseases，2019-01799, Cellular Dynamics behind Formation of Synovial Joints, 2019-01至2019-12
2. 瑞典卡罗林斯卡医学院, Foundation for Rheumatology Research from Karolinska Institutet, 2018-02782, Characterization of newly discovered chondrocyte progenitors and their potential to heal damaged articular cartilage, 2019-01至2019-12
3. 斯德哥尔摩共济会儿童之家基金会, Stiftelsen Frimurare Barnhuset I Stockholm Foundation, Characterization of a feedback loop from the growth plate to the GH/IGF1 system, 2019-04至2019-12
4. 瑞典卡罗林斯卡医学院，Alex and Eva Foundation from Karolinska Institutet，2017-00433，Characterization of newly discovered chondrocyte progenitors and their potential to heal damaged articular cartilage, 2017-01至2017-12
5. 瑞典卡罗林斯卡医学院，Loo and Han Osterman Foundation from Karolinska Institutet，2017-00116, Exploring regenerative potential of articular cartilage in relation to osteoarthritis, 2017-03至2018-02
6. 欧洲分子生物学协会 (European Molecular Biology Organization (EMBO))，EMBO Long-Term Fellowship, ALTF 2014-1296, Characterization of a feedback loop from the growth plate to the GH/IGF1 system, 2015-04至2017-03
参加科研项目：
1. 瑞典卡罗林斯卡医学院, SFO Stem cells and Regenerative medicine, 2018 Junior grant, A novel stem cell niche in the epiphyseal growth plate, 2018-2020,
2. 瑞典研究理事会(Swedish Research Council), Research grant, 2016-02835, Exploring regenerative potential of articular cartilage in relation to osteoarthritis, 2017-2020
谢梦博士专长于代谢生物学和发育生物学。主要研究兴趣集中于：
1. 环境和遗传条件对于脂肪组织多样性和可塑性的影响
2. 胚胎时期脊柱发育背后的细胞动力学和分子调控机制
3. 膝关节各组成部分之间在细胞和分子层面的区别与联系
Xie M, Gol'din P, Herdina AN, Estefa J, Medvedeva EV, Li L, Newton PT, Kotova S, Shavkuta B, Saxena A, Shumate LT, Metscher BD, Großschmidt K, Nishimori S, Akovantseva A, Usanova AP, Kurenkova AD, Kumar A, Arregui IL, Tafforeau P, Fried K, Carlström M, Simon A, Gasser C, Kronenberg HM, Bastepe M, Cooper KL, Timashev P, Sanchez S, Adameyko I, Eriksson A, Chagin AS. Secondary ossification center induces and protects growth plate structure. Elife. 2020 Oct 16;9:e55212. doi: 10.7554/eLife.55212.
Xie M, Chagin AS. The epiphyseal secondary ossification center: Evolution, development and function. Bone. 2020 Oct 19:115701. doi: 10.1016/j.bone.2020.115701.
Zhang Y, Annusver K, Sunadome K, Kameneva K, Edwards S, Kasper M, Chagin AS, Adameyko I*, Xie M*. Epiphyseal cartilage formation involves differential dynamics of various cellular populations during embryogenesis. Frontiers in Cell and Developmental Biology. 2020 Mar 5;8:122. doi: 10.3389/fcell.2020.00122. eCollection 2020. *Corresponding authors
Zhang Y, Kameneva P, Annusver K, Kasper M, Chagin AS, Adameyko I*, Xie M*. Cruciate ligament, patellar tendon and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds. Developmental Dynamics. 2020 Jun;249(6):711-722. doi: 10.1002/dvdy.158. * Corresponding authors
Xie M, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, Storer M, Fried K, Adameyko I, Dyachuk V, Chagin AS. Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15068-15073. doi: 10.1073/pnas.1900038116.
Xie M, Li JP. Heparan sulfate proteoglycan - A common receptor for diverse cytokines. Cell Signal. 2019 Feb;54:115-121. doi: 10.1016/j.cellsig.2018.11.022.
Xie M and Roy R. AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae. PLoS One. 2015 Jun 22;10(6):e0130480. doi: 10.1371/journal.pone.0130480.
Xie M and Roy R. The Causative Gene in Chanarian-Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. PLoS Genetics. 2015 Jun 17;11(6):e1005284. doi: 10.1371/journal.pgen.1005284.
Xie M and Roy R. Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Remodelling of Lipid Metabolism in C. elegans. Cell Metabolism. 2012 Sep 5;16(3):322-35.
Xie M, Alonso H and Roujeinikova A. An Improved Procedure for the Purification of Catalytically Active Alkane Hydroxylase from Pseudomonas putida GPo1. Appl Biochem Biotechnol. 2011 Oct;165(3-4):823-3.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, Sävendahl L, Chagin AS. A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature. 2019 Mar;567(7747):234-238. doi: 10.1038/s41586-019-0989-6.
Newton PT, Xie M, Medvedeva EV, Sävendahl L, Chagin AS. Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered. Bone Rep. 2018 Feb 24;8:64-71. doi: 10.1016/j.bonr.2018.02.006.
Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME, Xie M, Kicheva A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser M, Chagin AS, Fried K, Adameyko I. Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. Elife. 2018 Jun 13;7. pii: e34465. doi: 10.7554/eLife.34465.
Li L, Newton PT, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, Xie M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar AB, Warman ML, Barenius B, Adameyko I, Chagin AS. Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice. FASEB Journal 2017 Mar;31(3):1067-1084. doi: 10.1096/fj.201600918R.
Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J, Xie M, Petersen J, Pachnis V, Nicolis SK, Yu T, Sharpe P, Arenas E, Brismar H, Blom H, Clevers H, Suter U, Chagin AS, Fried K, Hellander A, Adameyko I. Analysis of neural crest-derived clones reveals novel aspects of facial development. Science Advances 2016 Aug 3;2(8):e1600060. doi: 10.1126/sciadv.1600060.
Andrew D, Xie M, Bottomley S, Wilce M and Roujeinikova A. Design, purification and characterization of the soluble variant of the integral membrane protein MotB for structural studies. J. R. Soc. Interface. 2013 Feb 6;10(79):20120717.
O’Neil J, Xie M, Hijnen M and Roujeinikova. Role of the MotB linker in the assembly and activation of the bacterial flagellar motor. Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1009-16.